AtLeg.666b7, Burnet's emendation of the transmitted λήθην to λήθῃ has been widely accepted. Newly discovered support for this emendation comes from an Arabic version or adaptation of Plato'sLaws, most likely Galen'sSynopsis, quoted by the polymath Abū-Rayḥān al-Bīrūnī (a.d.973–1048) asKitāb al-Nawāmīs li-Aflāṭunin his ethnographic work on India. I transliterate and translate the passage below, proposing two incidental emendations to the Arabic:wa-qāla l-aṯīniyyu fī l-maqālati l-tāniyati mina l-kitābi: lammā raḥima [sic proraḥimati] l-ālihatu ǧinsa l-bašari min aǧli annahū maṭbūʿun ʿalā l-taʿabi hayyaʾū lahum (...) aʿyādan li-l-ālihati wa-li-l-sakīnāti wa-li-ʾf-w-l-l-n mudabbiri l-sakīnāti wa-li-d-y-w-n-w-s-y-s māniḥi l-bašari l-ḫamrata dawāʾan lahum min ʿufūṣati l-šayḫūḫati li-yaʿūdū fityānan bi-l-duhūli ʿani l-kābati wa-ntiqāli ḫulqi l-nafsi [wa-yantaqila ḫulqu l-nafsiperhaps to be read] mina l-šiddati ilā l-salāmati [al-salāsatiprobably to be read].The Athenian said in the second book of the work [sc. theLaws]: The gods, taking pity on the human race since it was born for toil, established for them feast-days (dedicated) to the gods and to the Muses and to Apollo, overseer of the Muses, and to Dionysus, who gave human beings wine as a remedy for them against the bitterness of old age, so that they might be rejuvenated by forgetting sorrow and (by) the character of the soul changing [and (so that) the character of the soul might changeperhaps to be read] from severity into soundness [into tractabilityprobably to be read].The source of the latter part of the passage, that is, the description of Dionysus’ gift and its effect (māniḥi l-bašari…l-salāmati), has until now remained unidentified. In the notes to his translation, Sachau, followed by Gabrieli, correctly identified part ofLeg. 653c–d (θεοὶ … ἔδοσαν) as the origin of much of the passage (see n. 4). No previous scholarship, however, has noted that the latter part translates a passage inLeg.666b–c (τοῖς ἀνθρώποις … τὸ τῆς ψυχῆς ἦθος), here joined to the earlier passage (presumably by Bīrūnī’s source, that is, most likely Galen) on the hinge of their shared mention of Dionysus. (shrink)

The retrotransposon Long Interspersed Element 1 (LINE‐1 or L1) has played a major role in shaping the sequence composition of the mammalian genome. In our recent publication, “Heritable L1 retrotransposition in the mouse primordial germline and early embryo,” we systematically assessed the rate and developmental timing of de novo, heritable endogenous L1 insertions in mice. Such heritable retrotransposition events allow L1 to exert an ongoing influence upon genome evolution. Here, we place our findings in the context of earlier studies, and (...) highlight how our results corroborate, and depart from, previous research based on human patient samples and transgenic mouse models harboring engineered L1 reporter genes. In parallel, we outline outstanding questions regarding the stage‐specificity, regulation, and functional impact of embryonic and germline L1 retrotransposition, and propose avenues for future research in this field. -/- . (shrink)

We provide a comprehensive analysis of differences between socially responsible investment and conventional funds in terms of manager characteristics, performance and fund styles. We use holdings-based analysis to evaluate fund performance and style, which allows us to perform a more in-depth analysis than the extant literature. We find that SRI managers have longer tenure and are more likely to be a female. However, these differences do not result in any significant difference in the performance of SRI and conventional funds. Further, (...) it is possible to find an SRI fund of any style, although these funds are under-represented in value styles. (shrink)

Processed pseudogenes may serve as a genetic reservoir for evolutionary innovation. Here, we argue that through the activity of long interspersed element‐1 retrotransposons, processed pseudogenes disperse coding and noncoding sequences rich with regulatory potential throughout the human genome. While these sequences may appear to be non‐functional, a lack of contemporary function does not prohibit future development of biological activity. Here, we discuss the dynamic evolution of certain processed pseudogenes into coding and noncoding genes and regulatory elements, and their implication in (...) wide‐ranging biological and pathological processes. Also see the video abstract here: https://youtu.be/iUY_mteVoPI. (shrink)

Gene retrocopies are generated by reverse transcription and genomic integration of mRNA. As such, retrocopies present an important exception to the central dogma of molecular biology, and have substantially impacted the functional landscape of the metazoan genome. While an estimated 8,000–17,000 retrocopies exist in the human genome reference sequence, the extent of variation between individuals in terms of retrocopy content has remained largely unexplored. Three recent studies by Abyzov et al., Ewing et al. and Schrider et al. have exploited 1,000 (...) Genomes Project Consortium data, as well as other sources of whole‐genome sequencing data, to uncover novel gene retrocopies. Here, we compare the methods and results of these three studies, highlight the impact of retrocopies in human diversity and genome evolution, and speculate on the potential for somatic gene retrocopies to impact cancer etiology and genetic diversity among individual neurons in the mammalian brain. (shrink)

Whether ethics is too important to be left to the experts or so important that it must be is an age-old question. The emergence of clinical ethicists raises it again, as a question about professionalism. What role clinical ethicists should play in healthcare decision making – teacher, mediator, or consultant – is a question that has generated considerable debate but no consensus.

Reproductive proteins maintain species‐specific barriers to fertilization, affect the outcome of sperm competition, mediate reproductive conflicts between the sexes, and potentially contribute to the formation of new species. However, the specific proteins and molecular mechanisms that underlie these processes are understood in only a handful of cases. Advances in genomic and proteomic technologies enable the identification of large suites of reproductive proteins, making it possible to dissect reproductive phenotypes at the molecular level. We first review these technological advances and describe (...) how reproductive proteins are identified in diverse animal taxa. We then discuss the dynamic evolution of reproductive proteins and the potential selective forces that act on them. Finally, we describe molecular and genomic tools for functional analysis and detail how evolutionary data may be used to make predictions about interactions among reproductive proteins. (shrink)

Despite an abundance of research on inter-organizational trust, researchers are only beginning to understand the process of trust deterioration as an inter-organizational phenomenon. This paper presents a case study examining the deteriorating relationship between two international high-tech firms. We surveyed respondents from the supplier firm to identify major elements that reduced the supplier's trust in its customer, using the dimensions of trust identified by Mayer et al. (1995). While violations of ability, integrity, and benevolence all contributed to trust reduction, early (...) violations of trustee benevolence contributed importantly to trust deterioration. Over time, the relationship became "sensitive," and respondents reported many incidents of trust violation. Managers reported primarily integrity- and benevolence-related incidents, while no pattern emerged among operations personnel. We examine the results in light of Hosmer's (1995) ethically-based trust principles. The supplier and customer would likely differ in their opinion of whether the customer was acting "ethically." This suggests that scholars need to examine how many principles can be violated before trust is eliminated, and whether any of the principles are particularly salient in business relationships. (shrink)

The literature on public perceptions of, and attitudes towards, nanotechnology used in the agrifood sector is reviewed. Research into consumer perceptions and attitudes has focused on general applications of nanotechnology, rather than within the agrifood sector. Perceptions of risk and benefit associated with different applications of nanotechnology, including agrifood applications, shape consumer attitudes, and acceptance, together with ethical concerns related to environmental impact or animal welfare. Attitudes are currently moderately positive across all areas of application. The occurrence of a negative (...) or positive incident in the agri-food sector may crystallise consumer views regarding acceptance or rejection of nanotechnology products. •Acceptance of agrifood nanotechnology based on perceptions of risk, benefit and ethics.•Attitudes towards nanotechnology in general are currently moderately positive.•Occurrence of a major nanotechnology-related "event" may crystallise consumer attitude. (shrink)

In “Revive and Refuse,” Marshall et al. (2024) argue that many individuals who are revived from opioid overdoses have diminished decision-making capacity (DMC), given that so many of them have opio...

Perception of (and during) events is a necessary feature of any perceptual theory. Norman's dual-process approach cannot account for the perception of events without substantial interactions between the dorsal and ventral systems. These interactions, as outlined by Norman, are highly problematical. The necessity for interactions between the two systems makes the distinction useless.

A primary proposal of the Cowan target article is that capacity limits arise in working memory because only 4 chunks of information can be attended at one time. This implies a single, unitary attentional focus or resource; we instead propose that relatively independent attentional mech- anisms operate within different cognitive subsystems depending on the demands of the current stimuli and tasks.

Darwin himself suggested the idea of generalizing the core Darwinian principles to cover the evolution of social entities. Also in the nineteenth century, influential social scientists proposed their extension to political society and economic institutions. Nevertheless, misunderstanding and misrepresentation have hindered the realization of the powerful potential in this longstanding idea. Some critics confuse generalization with analogy. Others mistakenly presume that generalizing Darwinism necessarily involves biological reductionism. This essay outlines the types of phenomena to which a generalized Darwinism applies, and (...) upholds that there is no reason to exclude social or economic entities. (shrink)